Safety First: 12 Clinically Approved Benefits of CBD

Before diving into the 12 clinically proven benefits of CBD, let’s first discuss what cannabidiol (CBD) is!

Cannabidiol is a derivative from Cannabis sativa. However, cannabidiol is nonpsychoactive, meaning it will not hinder one’s mind or mental processes.

That means we can reap the benefits of CBD without experiencing any of the psychoactive (affecting brain function by altering perception, mood, consciousness, cognition, and or behavior) side effects that Cannabis sativa as a whole contains due to its Tetrahydrocannabinol (THC) content.


12 Clinically Approved Benefits of CBD


1. The Journal of Experimental Medicine published a study in 2012 which found that “CBD derivatives significantly suppress chronic inflammatory and neuropathic pain without causing apparent analgesic tolerance in rodents.”

Researchers have reason to believe that because CBD acts as a negative modulator of Cannabinoid receptor type 1 (CB1) it changes the shape of the CB1 receptor in which, CBD does not bind to CB1 or CB2 like THC does.

Instead, CBD has shown the glycine receptor (α3 GlyRs) mediates glycinergic cannabinoid-induced suppression of chronic pain. This study confirms that cannabinoids may be used as a method of treatment For inflammatory pain.


2. The Journal of Experimental Medicine conducted a study in 2012. They were searching for ways to treat neuropathic pain, a major clinical problem that’s extremely difficult to treat. Their research found that glycinergic cannabinoids suppress neuropathic pain without psychoactive side effect.


3. CBD interacts with serotonin receptors, which consequently are responsible for our mood and stress levels. Studies have shown CBD to affect -HT1A, which is a subtype of serotonin. It promotes a state of well-being in spite of the fact that the brain may interpret some external factors as being stressful.

Therefore, CBD oil is useful to those suffering from anxiety and looking to avoid being medicated with psychoactive drugs as a treatment.


4. Acne is something that affects the lives of many. Treatment often feels limited to over the counter topicals, prescription topicals or oral medications — all of which have side effects.

Acne, therefore, occurs because of excessive oil production, the buildup of dead skin, or bacterial infection. CBD can calm the sebaceous glands and aid in regulating oil production. Therefore, CBD helps in slowing down the production of sebum, which also reduces inflammation.


5. Insomnia is a sleep disorder that’s characterized by an individual having a difficult time sleeping. The National Institute of Health published a study conducted in 2013 which found acute administration of CBD increased total sleep time. CBD may have an intricate role in regulating sleep to assist those suffering from insomnia.


6. Depression is a mood disorder that causes one to feel persistent sadness and a loss of interest. Depression medications are Selective Serotonin Reuptake Inhibitors (SSRIs), which increase levels of a chemical messenger in the brain called serotonin.

If someone has an imbalance of serotonin, this is a contributing factor to depression, anxiety, poor mood, sexual dysfunction, OCD and stress.

CBD directly interacts with serotonin and dopamine receptors that influence brain activity and the release of serotonin and dopamine throughout the body.

In 2011, researchers found “ample evidence that endocannabinoids are important regulators of stress responses.”

So it can be assumed that, during states of depression, plant cannabinoids such as CBD can regulate one’s response to stressful situations.


7. A 2013 study published in the British Journal of Clinical Pharmacology reports that CBD protects against the vascular damage caused by a high glucose environment, inflammation or the induction of type 2 diabetes in animal models.

Also, CBD has been shown to reduce the vascular hyperpermeability, meaning that CBD promotes cardiovascular health.


8. CBD has undergone many studies and proven to be quite beneficial. In 2008, European Review for Medical and Pharmacological Sciences found that “Overall, modulation of the gut endogenous cannabinoid system may provide a useful therapeutic target for disorders of gastrointestinal motility.”

That means CBD can benefit those whose digestive tract does not function with their normal strength and coordination.


9. Cannabis has been used for centuries to suppress nausea and vomiting. However, research has shown that CBD helps alleviate nausea and vomiting.

A 2012 study published in the British Journal of Clinical Pharmacology found that CBD benefits including possessing anti-nausea and antiemetic effects when it was administered to rats.


10. In 2006, the National Institute of Health shared a study which concluded that CBD treatment significantly reduced the incidence of diabetes in non-obese diabetic mice from an incidence of 86 percent in non-treated mice to an incidence of 30 percent in CBD-treated mice.

CBD has also been shown to reduce plasma levels of pro-inflammatory cytokines.


11. Most illnesses and disorders stem from an impairment within the body’s regulation. Erectile dysfunction is among them.

CBD helps to regulate the system through elevating endocannabinoids, opening pathways and ion channels in the brain, and stimulating receptors. These cannabinoid receptors give CBD a lot of room to help you throughout your body.

These receptors are located all over your organs, tissues, and cells. Therefore, if you have depression, fatigue, PTSD, toxicity, inflammation, etc. that are causing or contributing to erectile dysfunction, CBD could be of great assistance in replenishing your sexual health.


12. Many studies have shown that CBD benefits include possessing antiproliferative, pro-apoptotic effects which inhibit cancer cell migration, adhesion and or invasion. A 2006 study published in the Journal of Pharmacology and Experimental Therapeutics found that CBD potently and selectively inhibited the growth of different breast tumor cell lines and exhibited significantly less potency in non-cancer cells.

Researchers in 2011 found the cellular mechanism through which CBD can induce cell death in breast cancer cells. They also found that the effective concentrations of CBD in tumor cells have little effect on non-tumorigenic, mammary cells.